4-(1H-tetrazol-5-yl)aniline → HCID 59588059, compound

HRID 40739Notes

Reaction equation

HRID 40739 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([N:16]3[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18][CH2:17]3)=[C:12]([CH:15]=2)[C:13]#[N:14])[CH:5]=[CH:4][N:3]=1.[N:23]1[NH:24][N:25]=[N:26][C:27]=1[C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1>>[N:26]1[NH:25][N:24]=[N:23][C:27]=1[C:28]1[CH:34]=[CH:33][C:31]([NH:32][C:2]2[N:7]=[C:6]([C:8]3[CH:9]=[CH:10][C:11]([N:16]4[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18][CH2:17]4)=[C:12]([CH:15]=3)[C:13]#[N:14])[CH:5]=[CH:4][N:3]=2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 10792164-(1H-tetrazol-5-yl)anilineHCID 59588188HCID 59588188, compound

Product 1

HCID 59588059HCID 59588059, compound

Procedure

5-2-(4-(2H-Tetrazol-5-yl)phenylamino)pyrimidin-4-yl)-2-(4-hydroxypiperidin-1-yl)benzonitrile was obtained by following procedure E using 5-(2-chloropyrimidin-4-yl)-2-(4-hydroxypiperidin-1-yl)benzonitrile and 4-(2H-tetrazol-5-yl)aniline. 1H NMR (DMSO-d6, 400 MHz) δ 10.09 (s, 1H), 8.61 (d, 1H), 8.50 (d, 1H), 8.38 (dd, 1H), 8.06 (d, 2H), 8.00 (d, 2H), 7.55 (d, 1H), 7.32 (d, 1H), 3.72 (m, 1H), 3.61 (m, 2H), 3.13 (m, 2H), 1.89 (m, 2H), 1.59 (m, 2H). MS (ESI) 440.10 (M+H).

Sources & evidence

ORD record
ord-10d3133dcda4402080c3d3883e02afd1
Source dataset
uspto-grants-2013_09
Patent number
US08530480B2

Reaction notes

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