4-Chlorophenyl Isocyanate → 1-[3-(4-Chloro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(4-Chloro-phenyl)-urea

Participants

Reaction Steps

3-(4-Chloro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine was treated with 4-chlorophenyl isocyanate in a similar manner as described in Example 1.53, providing 12 mg (30%) of Compound 26: LCMS m/z (%)=393 (M+H37Cl, 60), 391 (M+H35Cl, 100). 1H NMR (400 MHz, DMSO-d6) δ: 8.80 (s, 1H), 8.71 (s, 1H), 7.62 (s, 1H), 7.57 (dd, J1=8 Hz, J2=4 Hz, 1H), 7.49 (dd, J1=8 Hz, J2=2 Hz, 2H), 7.39 (d, J=4 Hz, 1H), 7.33 (dd, J1=8 Hz, J2=2 Hz, 2H), 7.17 (d, J=8 Hz, 1H), 3.77 (s, 3H), 3.62 (s, 3H).

Provenance & Evidence