Morpholine → 3-Bromo-5-morpholinobenzonitrile

HRID 40745Notes

Reaction equation

HRID 40745 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](F)[CH:9]=1)[C:5]#[N:6].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:9]=1)[C:5]#[N:6]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 27833303-Bromo-5-fluorobenzonitrile

Product 1

HCID 446273673-Bromo-5-morpholinobenzonitrileYield 81%

Procedure

3-bromo-5-morpholinobenzonitrile was prepared according procedure M from 3-bromo-5-fluorobenzonitrile and morpholine in 81% yield.

Sources & evidence

ORD record
ord-f70f5638744e44248d8c20a4ba770f7c
Source dataset
uspto-grants-2013_09
Patent number
US08530480B2

Reaction notes

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