Benzyl isocyanate → HCID 23139456, compound

Participants

Reaction Steps

3-(4-Chloro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine (59 mg, 0.25 mmol) was treated with benzyl isocyanate (34 μL, 0.28 mmol) in a similar manner to Example 1.53, providing 42.7 mg (46.1%) of Compound 105: LCMS m/z (%)=371 (M+H35Cl, 100), 373 (M+H37Cl, 40). 1H NMR (400 MHz, DMSO-d6) δ: 8.55 (s, 1H), 7.58 (s, 1H), 7.50 (dd, J1=8 Hz, J2=4 Hz, 1H), 7.33 (m, 5H), 7.30 (d, J=4 Hz, 1H), 7.10 (d, J=12 Hz, 1H), 6.58 (s, 1H), 4.28 (s, 2H), 3.73 (s, 3H), 3.58 (s, 3H).

Provenance & Evidence