HRID407550

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)C4C3)cc(-c3nc(C(C)C)cs3)nc2c1C

HCID66810935

未命名化合物

结构：CCc1c(OC)ccc2c(O)cc(-c3nc(C(C)C)cs3)nc12

HCID178437263

未命名化合物

PRODUCTS

生成物

结构：CCc1c(OC)ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)C4C3)cc(-c3nc(C(C)C)cs3)nc12

HCID66871155

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 8-ethyl-4-hydroxy-2-(4-isopropylthiazole-2-yl)-7-methoxyquinoline (69) and intermediate 43 following the procedure (Steps D-F) reported for the preparation of 17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methyl-quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (46): m/z=661 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2bcc67535254339982fa22d17ebbdd8
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08754106B2
来源说明: uspto-grants-2014_06

反应 SMILES

[CH2:1]([C:3]1[C:4]([O:22][CH3:23])=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([C:13]1[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=1)[CH:9]=[C:8]2[OH:21])[CH3:2].C(C1N=C(C2C=C(O[CH:43]3[CH2:60][CH:59]4[CH:45]([C:46](=[O:66])[N:47]([CH3:65])[CH2:48][CH2:49][CH2:50][CH2:51][CH:52]=[CH:53][CH:54]5[C:56]([C:62]([OH:64])=[O:63])([NH:57][C:58]4=[O:61])[CH2:55]5)[CH2:44]3)C3C(=C(C)C(OC)=CC=3)N=2)SC=1)(C)C>>[CH2:1]([C:3]1[C:4]([O:22][CH3:23])=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([C:13]1[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=1)[CH:9]=[C:8]2[O:21][CH:43]1[CH2:60][CH:59]2[CH:45]([C:46](=[O:66])[N:47]([CH3:65])[CH2:48][CH2:49][CH2:50][CH2:51][CH:52]=[CH:53][CH:54]3[C:56]([C:62]([OH:64])=[O:63])([NH:57][C:58]2=[O:61])[CH2:55]3)[CH2:44]1)[CH3:2]