C35H42N4O6S → 17-[8-Ethyl-2-(4-isopropylthiazole-2-yl)-7-methoxyquinolin-4-yl-oxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

HRID 407550Notes

Reaction equation

[CH2:1]([C:3]1[C:4]([O:22][CH3:23])=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([C:13]1[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=1)[CH:9]=[C:8]2[OH:21])[CH3:2].C(C1N=C(C2C=C(O[CH:43]3[CH2:60][CH:59]4[CH:45]([C:46](=[O:66])[N:47]([CH3:65])[CH2:48][CH2:49][CH2:50][CH2:51][CH:52]=[CH:53][CH:54]5[C:56]([C:62]([OH:64])=[O:63])([NH:57][C:58]4=[O:61])[CH2:55]5)[CH2:44]3)C3C(=C(C)C(OC)=CC=3)N=2)SC=1)(C)C>>[CH2:1]([C:3]1[C:4]([O:22][CH3:23])=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([C:13]1[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=1)[CH:9]=[C:8]2[O:21][CH:43]1[CH2:60][CH:59]2[CH:45]([C:46](=[O:66])[N:47]([CH3:65])[CH2:48][CH2:49][CH2:50][CH2:51][CH:52]=[CH:53][CH:54]3[C:56]([C:62]([OH:64])=[O:63])([NH:57][C:58]2=[O:61])[CH2:55]3)[CH2:44]1)[CH3:2]

Participants

Reactant 2

HCID 66810935C35H42N4O6S

HCID 178437263HCID 178437263, compound

Product 1

HCID 6687115517-[8-Ethyl-2-(4-isopropylthiazole-2-yl)-7-methoxyquinolin-4-yl-oxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

Procedure

The title compound was prepared from 8-ethyl-4-hydroxy-2-(4-isopropylthiazole-2-yl)-7-methoxyquinoline (69) and intermediate 43 following the procedure (Steps D-F) reported for the preparation of 17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methyl-quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (46): m/z=661 (M+H)+.

Sources & evidence

ORD record: ord-e2bcc67535254339982fa22d17ebbdd8
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754106B2

Reaction notes

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