HRID407588

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)C4C3)cc(-c3nccs3)nc2c1C

HCID66870807

未命名化合物

HCID178487714

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)C4C3)cc(-n3nc(C)cc3C)nc2c1C

HCID66871174

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-hydroxy-2-(3,5-dimethylpyrazol-1-yl)-7-methoxy-8-methylquinoline (129) and intermediate 26 following the procedure (Step D-F) reported for the preparation of 17-[7-methoxy-8-methyl-2-(thiazol-2-yl)quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (29): m/z=616 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-35bb065bd46843f79e1152992c744fdc
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08754106B2
来源说明: uspto-grants-2014_06

反应 SMILES

[OH:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:14])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([N:15]2[C:19]([CH3:20])=[CH:18][C:17]([CH3:21])=[N:16]2)[CH:3]=1.COC1C(C)=C2C(C(O[CH:41]3[CH2:58][CH:57]4[CH:43]([C:44](=[O:64])[N:45]([CH3:63])[CH2:46][CH2:47][CH2:48][CH2:49][CH:50]=[CH:51][CH:52]5[C:54]([C:60]([OH:62])=[O:61])([NH:55][C:56]4=[O:59])[CH2:53]5)[CH2:42]3)=CC(C3SC=CN=3)=N2)=CC=1>>[CH3:21][C:17]1[CH:18]=[C:19]([CH3:20])[N:15]([C:4]2[CH:3]=[C:2]([O:1][CH:41]3[CH2:58][CH:57]4[CH:43]([C:44](=[O:64])[N:45]([CH3:63])[CH2:46][CH2:47][CH2:48][CH2:49][CH:50]=[CH:51][CH:52]5[C:54]([C:60]([OH:62])=[O:61])([NH:55][C:56]4=[O:59])[CH2:53]5)[CH2:42]3)[C:11]3[C:6](=[C:7]([CH3:14])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[N:16]=1