3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propane-1-sulfonyl chloride → HCID 178456452, compound

HRID 40760Notes

Reaction equation

HRID 40760 reaction equation
C1(=O)N(CC)C(=O)C2=CC=CC=C12.[CH3:14][NH:15][SH:16](=[O:18])=[O:17].[C:19]1(=[O:36])[N:23]([CH2:24][CH2:25][CH2:26]S(Cl)(=O)=O)[C:22](=[O:31])[C:21]2=[CH:32][CH:33]=[CH:34][CH:35]=[C:20]12>>[C:22]1(=[O:31])[N:23]([CH2:24][CH2:25][CH3:26])[C:19](=[O:36])[C:20]2=[CH:35][CH:34]=[CH:33][CH:32]=[C:21]12.[CH3:14][NH:15][SH:16](=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 154532703-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propane-1-sulfonyl chlorideHCID 178462848HCID 178462848, compound

Product 1

HCID 178456452HCID 178456452, compound

Procedure

Synthesised according to the method described for 2-phthalimidoethane-N-methylsulfonamide from 3-phthalimidopropanesulfonyl chloride (2.50 g). Yield: 854 mg (35%). 1H-NMR (CDCl3) δ (ppm) 7.82-7.76 (m, 2H), 7.72-7.64 (m, 2H), 4.13 (br s, 1H), 3.78 (t, J=6.8 Hz, 2H), 3.07-2.99 (m, 2H), 2.74 (d, J=5.2 Hz, 3H), 2.21-1.18 (m, 2H).

Workup

  1. customSynthesised

Sources & evidence

ORD record
ord-90928cb4133e481199947efa5edb637a
Source dataset
uspto-grants-2013_09
Patent number
US08530486B2

Reaction notes

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