反应详情

A 500-mL bottle was purged with nitrogen and charged with 105a (5.8 g, 18 mmol), 10% palladium on carbon (50% wet, 2.0 g) and ethanol (200 mL). It was evacuated, charged with hydrogen gas, and stirred for 16 h at room temperature. The hydrogen was then removed in vacuo and replaced with nitrogen. The catalyst was removed by filtration through a pad of CELITE® and the filtrate concentrated under reduced pressure to afford 105b as a brown solid (4.9 g, 96%). LCMS: [M+H]+ 293

1. customA 500-mL bottle was purged with nitrogen
2. customIt was evacuated
3. additioncharged with hydrogen gas
4. customThe hydrogen was then removed in vacuo
5. customThe catalyst was removed by filtration through a pad of CELITE®
6. concentrationthe filtrate concentrated under reduced pressure