tert-Butyl (3S)-4-{6-[(5-chloro-2-methoxypyridin-3-yl)amino]pyridin-3-yl}-3-methylpiperazine-1-carboxylate → (S)-5-Chloro-3-(5-(2-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one

Participants

Reaction Steps

A solution of 138a (1.0 g, 2.3 mmol) in dioxane/HCl (30 mL) was stirred at 100° C. for 2 h. It was then evaporated under reduced pressure to afford 138b (1.48 g, crude) as a yellow solid. MS-ESI: [M+H]+ 320.3

Provenance & Evidence