反应详情

A 50-mL single-neck round-bottomed flask was purged with nitrogen and charged with 155a (0.20 g, 0.89 mmol), 10% palladium on carbon (50% wet, 89 mg), and methanol (10 mL). The mixture was evacuated, charged with hydrogen gas, and stirred for 2 h at room temperature. The hydrogen was then evacuated and nitrogen was charged into the bottle. The catalyst was removed by filtration through a pad of CELITE® and the filtrate was concentrated under reduced pressure to afford 155b (140 mg, 81%). MS: [M+H]+ 195.1

1. customA 50-mL single-neck round-bottomed flask was purged with nitrogen
2. customThe mixture was evacuated
3. additioncharged with hydrogen gas
4. customThe hydrogen was then evacuated
5. additionnitrogen was charged into the bottle
6. customThe catalyst was removed by filtration through a pad of CELITE®
7. concentrationthe filtrate was concentrated under reduced pressure