3,5-Dibromo-1-methylpyridin-2(1H)-one → HCID 86684083, compound

HRID 407822Notes

Reaction equation

HRID 407822 reaction equation
[F:1][CH:2]([F:9])[N:3]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4]1.Br[C:11]1[C:12](=[O:19])[N:13]([CH3:18])[CH:14]=[C:15]([Br:17])[CH:16]=1>>[Br:17][C:15]1[CH:16]=[C:11]([NH:8][C:6]2[CH:5]=[N:4][N:3]([CH:2]([F:9])[F:1])[N:7]=2)[C:12](=[O:19])[N:13]([CH3:18])[CH:14]=1

Participants

3

Reactant 2

HCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-oneHCID 86684082HCID 86684082, compound

Product 1

HCID 86684083HCID 86684083, compoundYield 70%

Procedure

Following the procedure of Example 151f, and starting with 159b (170 mg, 1.25 mmol, 1.0 eq.) and 3,5-dibromo-1-methylpyridin-2(1H)-one (504 g, 1.89 mmol, 1.5 eq.) afforded 159c as a light yellow solid (280 mg, 70%). MS-ESI:[M+H]+ 320.1.

Sources & evidence

ORD record
ord-e76dee599b404c428cc2e6478a0b92ae
Source dataset
uspto-grants-2014_06
Patent number
US08754077B2

Reaction notes

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