HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4H,5H,6H-pyrrolo(1,2-b)pyrazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-2-ylcarbamate | HCID 86684089 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4H,5H,6H-pyrrolo(1,2-b)pyrazol-2-amine | HCID 67537062 | — |
Reaction Steps
To a solution of 162b (45 mg, 0.20 mmol) in dichloromethane (1.5 mL) was added trifluoroacetic acid (1 mL) at room temperature. The solution was stirred for 5 h. It was then concentrated under reduced pressure to afford 162c which was used in the next step without further purification. MS-ESI: [M+H]+ 124.3
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754077B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-2daf320a466c408299a39e9d4fc474fb |
| Source note | uspto-grants-2014_06 |