反应详情

Iodine (0.10 g, 0.38 mmol) is added to a solution of (1RS,2SR,6RS,7SR)-10-oxa-tricyclo[5.2.1.02,6]decane-3,5-dione (2.1 g, 12.65 mmol) in methanol (50 ml) and the reaction mixture is stirred for 2 hours at room temperature. The solvent is then removed under reduced pressure, dichloromethane is added and the organic layer is washed with saturated aqueous sodium thiosulfate solution, water and brine. The organic layer is dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated under reduced pressure to give (1RS,2SR,6RS,7SR)-5-methoxy-10-oxatricyclo[5.2.1.02,6]dec-4-en-3-one and used without further purification in the next step.

1. customThe solvent is then removed under reduced pressure, dichloromethane
2. additionis added
3. washthe organic layer is washed with saturated aqueous sodium thiosulfate solution, water and brine
4. dry with materialThe organic layer is dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. customthe filtrate is evaporated under reduced pressure