HCID 86688070, compound → HCID 67469761, compound

Participants

Reaction Steps

A solution of tert-butyl 1-(5-ethylpyrimidin-2-yl)piperidin-4-ylcarbamate (3.2 g, 10 mmol) in 50% TFA/CH2Cl2 (30 mL) was stirred at ambient temperature for 1 hour. The mixture was concentrated in vacuo. The residue was dissolved in EtOAc (200 mL) and washed with saturated sodium carbonate (200 mL) then brine. The combined organic layers were dried over MgSO4, filtered and concentrated in vacuo to yield (1-(5-ethylpyrimidin-2-yl)piperidin-4-amine (2.2 g, 11 mmol, 100%). Mass spectrum (apci) m/z=207.1 (M+H).

Provenance & Evidence