HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (S)-tert-butyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-ylamino)-4-(methylthio)-1-oxobutan-2-ylcarbamate methyliodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | (S)-tert-butyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-ylamino)-4-(methylthio)-1-oxobutan-2-ylcarbamate | HCID 67469820 | — |
| Product | (S)-tert-butyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-ylamino)-4-(methylthio)-1-oxobutan-2-ylcarbamate methyliodide | HCID 86688086 | 120% |
Reaction Steps
A solution of (S)-tert-butyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-ylamino)-4-(methylthio)-1-oxobutan-2-ylcarbamate (4.4 g, 10 mmol) in neat methyl iodide (22 mL, 340 mmol) stirred at ambient temperature for 18 hours. The reaction was evaporated to dryness to yield (S)-tert-butyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-ylamino)-4-(methylthio)-1-oxobutan-2-ylcarbamate methyliodide (7 g, 12 mmol, >95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754226B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-e386d2f0073e48ee835c7d1476fcb586 |
| Source note | uspto-grants-2014_06 |