Diisopropylethylamine → HCID 54670246, compound

Participants

Reaction Conditions

Reaction Steps

(3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-1-(piperidin-4-yl)pyrrolidin-2-one hydrochloride (0.03 g, 0.073 mmol) was dissolved in DMF (2 mL) and 2,5-dichloropyrazine (0.012 g, 0.081 mmol) and Hunig's base (0.040 mL, 0.22 mmol) were added. The reaction was heated at 100° C. for 4 hours. The reaction was cooled and concentrated. The residue was purified by reverse phase chromatography (5 to 95% ACN in water) to afford (3S,4S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxypyrrolidin-2-one (0.0027 g, 0.0056 mmol, 7.6% yield). Mass spectrum (apci) m/z=485.2 (M+H).

Provenance & Evidence