HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-benzyl 2-oxo-1,4'-bipiperidin-3-ylcarbamate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (S)-tert-butyl 3-(benzyloxycarbonylamino)-2-oxo-1,4'-bipiperidine-1'-carboxylate | HCID 58787267 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-benzyl 2-oxo-1,4'-bipiperidin-3-ylcarbamate hydrochloride | HCID 86688092 | 100% |
Reaction Steps
A flask was charged with (S)-tert-butyl 3-(benzyloxycarbonylamino)-2-oxo-1,4′-bipiperidine-1′-carboxylate (Example 39, Steps A-B; 5.0 g, 12 mmol), CH2Cl2 (50 mL), and methanol (5 mL), 4N HCl in dioxane (29 mL, 116 mmol) was added and the reaction stirred overnight. The reaction was concentrated to afford crude (S)-benzyl 2-oxo-1,4′-bipiperidin-3-ylcarbamate hydrochloride (4.3 g, 100%) which was taken forward without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754226B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-73d57c7784e0414f9a9b25b1b228621f |
| Source note | uspto-grants-2014_06 |