反应详情

(S)-1′-(5-acetylpyridin-2-yl)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1,4′-bipiperidin-2-one (0.310 g, 0.612 mmol) was dissolved in methanol (5 mL). NaBH4 (0.0232 g, 0.612 mmol) was added slowly and stirred at ambient temperature for 1 hour. The reaction was concentrated and purified over silica gel (50-100% EtOAc in hexanes) to afford (3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1′-(5-(1-hydroxyethyl)pyridin-2-yl)-1,4′-bipiperidin-2-one (0.265 g, 0.469 mmol, 76.6% yield). Mass spectrum (apci) m/z=509.2 (M+H).

1. concentrationThe reaction was concentrated
2. custompurified over silica gel (50-100% EtOAc in hexanes)