Hydrochloric Acid → HCID 67470549, compound

Participants

Reaction Steps

A flask was charged with (S)-tert-butyl 3-(2,6-difluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4′-bipiperidine-1′-carboxylate (1.2 g, 2.46 mmol), HCl (6.15 mL, 24.6 mmol), DCM (25 mL), and methanol (1 mL). The reaction mixture was stirred at ambient temperature overnight. The organic solvents were removed under reduced pressure to afford (S)-3-(2,6-difluoro-4-(methylsulfonyl)phenylamino)-[1,4′-bipiperidin]-2-one hydrochloride (0.986 g, 94.5% yield). Mass spectrum (apci) m/z=388.2 (M+H).

Provenance & Evidence