Acetohydrazide → (S)-tert-butyl 4-(3-(4-(2-acetylhydrazinecarbonyl)-2-fluorophenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Participants

Reaction Steps

(S)-4-(1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoic acid (834 mg, 1.97 mmol), acetohydrazide (219 mg, 2.96 mmol) and N-ethyl-N-isopropylpropan-2-amine (1375 μL, 7.90 mmol) were dissolved in CH2Cl2 (20 mL) and bis(2-oxooxazolidin-3-yl)phosphinic chloride (2010 mg, 7.90 mmol) was added and stirred at ambient temperature for 3 hours. The reaction was poured into water, extracted with EtOAc, washed with brine, dried over Na2SO4, filtered and concentrated to afford crude (S)-tert-butyl 4-(3-(4-(2-acetylhydrazinecarbonyl)-2-fluorophenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate (960 mg, 2.01 mmol, 102% yield) which was taken forward without further purification.

Provenance & Evidence