Hydrochloric Acid → (S)-benzyl 2-oxo-1,4'-bipiperidin-3-ylcarbamate hydrochloride

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Reaction Steps

A flask was charged with (S)-tert-butyl 3-(benzyloxycarbonylamino)-2-oxo-1,4′-bipiperidine-1′-carboxylate (Example 39, Steps A-B; 10.0 g, 23.2 mmol), DCM (60 mL), methanol (6 mL), HCl (57.9 mL, 232 mmol) and the reaction was stirred overnight. The organic solvents were removed under reduced pressure to provide (S)-benzyl 2-oxo-[1,4′-bipiperidin]-3-ylcarbamate hydrochloride (8.52 g, 100% yield). Mass spectrum (apci) m/z=332.2 (M+H).

Provenance & Evidence