Hydrochloric Acid → (S)-3-(4-bromo-2-fluoro-5-methylphenoxy)-1-(piperidin-4-yl)pyrrolidin-2-one hydrochloride

Participants

Reaction Steps

(S)-tert-butyl 4-(3-(4-bromo-2-fluoro-5-methylphenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate (2.3 g, 4.9 mmol) was dissolved in CH2Cl2:MeOH (9:1, 50 mL). 4N HCl in dioxane (10 mL) was added and the reaction stirred at ambient temperature overnight. The reaction was concentrated to afford crude (S)-3-(4-bromo-2-fluoro-5-methylphenoxy)-1-(piperidin-4-yl)pyrrolidin-2-one hydrochloride (2.0 g, 4.9 mmol, 101% yield) which was used without further purification.

Provenance & Evidence