Metformin Hydrochloride → HCID 178484382, compound

HRID 408060Notes

Reaction equation

HRID 408060 reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3]

Participants

3

Reactant 1

HCID 14219Metformin Hydrochloride2×

Product 1

HCID 178484382HCID 178484382, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Metformin hydrochloride is screened through 1 mm sieve. Screened metformin hydrochloride is granulated in a fluid bed granulator with a solution of povidone in demineralized water and dried in the same device. The dried granulate is screened through a 1 mm sieve. The obtained granulate, microcrystalline cellulose and hydroxypropylmethylcellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained. The final blend is compressed into a bilayer tablet as disclosed in Examples 11 in 12.

Workup

  1. customdried in the same device
  2. additionPre-sieved magnesium stearate is added to the obtained blend
  3. customis obtained

Sources & evidence

ORD record
ord-f283e73e0f2d41218d5c0e6e1bfc4ebe
Source dataset
uspto-grants-2014_06
Patent number
US08758815B2

Reaction notes

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