反应详情

The 2-amino-3-chlorobenzenthiol (550 mg, 3.95 mmol) was dissolved in EtOH (10 mL) followed by KOH (220 mg, 3.95 mmol). To this mixture was added a solution of 1,2-dichloro-3-nitrobenzene (760 mg, 3.95 mmol) in EtOH (10 mL). The resulting reaction mixture was refluxed for 8 h to 12 h. The reaction was allowed to cool to room temperature and the residue was extracted with EtOAc and 1 mol dm−3 H3PO4. The organic layer was dried over MgSO4, filtered and evaporated to give a crude material. This crude material was purified by flash silica gel chromatography.

1. customThe resulting reaction mixture
2. temperaturewas refluxed for 8 h to 12 h
3. extractionthe residue was extracted with EtOAc and 1 mol dm−3 H3PO4
4. dry with materialThe organic layer was dried over MgSO4
5. filtrationfiltered
6. customevaporated