Hydrochloric Acid → 2,4-Diamino-6-ethyl-5-(3-(2-(3-carboxypropoxy)phenoxy)propoxy)pyrimidine hydrochloride

Participants

Reaction Steps

To a suspension of 2,4-diamino-6-ethyl-5-(3-(2-(3-carboxypropoxy)phenoxy)propoxy)pyrimidine (0.3904 g, 1 mmol) in water (1 mL) was added one equivalent of concentrated HCl. The titled compound was obtained, after trituration of the reaction mixture with diethyl ether, as a white crystalline solid (0.4055 g, 95%). 1H NMR (400 MHz, DMSO-d6): 1.09 (3H, t, J=7.5 Hz), 1.90 (2H, m), 2.18 (2H, m), 2.38 (2H, t, J=7.3 Hz), 2.48 (2H, q, J=7.5 Hz), 3.89 (2H, t, J=6.1 Hz), 3.95 (2H, t, J=6.4 Hz), 4.12 (2H, t, J=6.0 Hz), 6.86-6.90 (2H, m), 6.95-7.02 (2H, m), 7.81 (1H, bs), 8.14 (1H, bs), 8.18 (1H, bs), 12.34 (1H, bs).

Provenance & Evidence