Benzyl 3-((tert-butoxycarbonyl)amino)-3-methylpiperidine-1-carboxylate → Tert-butyl (3-methylpiperidin-3-yl)carbamate

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Reaction Steps

Benzyl 3-(tert-butoxycarbonylamino)-3-methylpiperidine-1-carboxylate (1.4 g, 4.0 mmol) and 10% Pd/C (0.21 g, 0.2 mmol) in MeOH (20 mL) were stirred under an H2 atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration and washed with methanol. The filtrate was concentrated to give tert-butyl 3-methylpiperidin-3-ylcarbamate (0.62 g, 72% yield) as a solid.

Provenance & Evidence