反应详情

To a solution of 2 gr of 3-nitropropionic acid (41) in 30 mL of ethanol add catalytic amount of concentrated sulphuric acid (0.8 mL) and reflux overnight. Then add water and extracted with ethylacetate. The organic layer was washed with saturated sodium bicarbonate solution, saturated sodium chloride and water. Purification from column gives ethyl 3-nitropropionic acid (26) as pale yellow liquid with boiling point 92° C. at 2.5 torr.

1. temperaturereflux overnight
2. extractionThen add water and extracted with ethylacetate
3. washThe organic layer was washed with saturated sodium bicarbonate solution, saturated sodium chloride and water
4. customPurification from column