Nitrogen → 2-(8-Methoxyquinazolin-2-yl)thiazole

Participants

Reaction Conditions

Reaction Steps

2-Chloro-8-methoxyquinazoline (1.0 eq), and thiazol-2-ylzinc(II) bromide (1M in THF, 3 eq) was degassed by anhydrous N2 stream for 5 min followed by the addition of Pd(dppf)Cl2-DCM (0.1 eq). The reaction mixture was stirred at 50° C. for 1 hour. Solvents were removed under reduced pressure. The crude product was purified by column (10% methanol in ethyl acetate:hexanes=1:1) to give 2-(8-methoxyquinazolin-2-yl)thiazole (20%). LC/MS (m/z): 243.9 (MH+), Rt=0.68.

Provenance & Evidence