N-bromobutanimide → HCID 178519375, compound

Participants

Reaction Steps

To a solution of 20 g (137 mmol) 1H-indazole-5-carbaldehyde in acetonitrile (580 ml), 28 g (157 mmol) 1-bromopyrrolidine-2,5-dione were added over 20 min at room temperature. The resulting suspension was stirred under reflux for 30 min, then cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in ethyl acetate (1500 ml), and the solution was washed with water and with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude product was triturated with ethyl acetate. After filtration, the precipitate was dried under vacuum to yield the title compound as a white solid (30.9 g, 75% of th.).

Provenance & Evidence