sodium (1Z)-1-cyanoprop-1-en-2-olate → HCID 178467934, compound

HRID 408543Notes

Reaction equation

HRID 408543 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1[CH:12]=O.[C:14](/[CH:16]=[C:17](\[O-:19])/[CH3:18])#[N:15].[Na+]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1/[CH:12]=[C:16](/[C:17](=[O:19])[CH3:18])\[C:14]#[N:15]

Participants

3

Reactant 2

HCID 23687916sodium (1Z)-1-cyanoprop-1-en-2-olateHCID 178434325HCID 178434325, compound

Product 1

HCID 178467934HCID 178467934, compound

Procedure

Following the procedure described for Example 2A, the title compound was prepared using 2.74 g (15.5 mmol) 6-fluoro-3-methyl-1H-indazole-5-carbaldehyde (Example 17A) and 2.6 g (24.8 mmol) sodium (1Z)-1-cyanoprop-1-en-2-olate to yield 1.6 g (42% of th.) of the crude product which was used in the next step without further purification.

Sources & evidence

ORD record
ord-8eaf4d7ba9af4445b580a393c5304eef
Source dataset
uspto-grants-2014_06
Patent number
US08759341B2

Reaction notes

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