Ammonium Acetate → HCID 178428414, compound

Participants

Reaction Steps

The title compound was prepared from 200 mg (0.888 mmol) (2E)-2-[(3-methyl-1H-indazol-5-yl)-methylidene]-3-oxobutanenitrile (Example 2A), 126 mg (0.888 mmol) 5,5-dimethyldihydro-2H-pyran-2,4(3H)-dione [preparation: US 2006/0014826-A1 (Intermediate 6)] and 102 mg (1.332 mmol) ammonium acetate in analogy to the procedure described in Example 1 yielding 51 mg (16% of th.) after purification by preparative RP-HPLC (acetonitrile/water+0.1% TFA gradient) followed by flash chromatography (silica gel; ethyl acetate/cyclohexane gradient, final mixture 5:1 v/v).

Provenance & Evidence