Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 2-(Chloromethyl)-1-benzothiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-(Hydroxymethyl)benzo[b]thiophene | HCID 2776335 | — |
| 생성물 | 2-(Chloromethyl)-1-benzothiophene | HCID 12813837 | — |
반응 단계
A solution of benzo[b]thiophen-2-yl-methanol (1 eq.) in thionyl chloride was stirred at 20° C. for 1 h. The crude was concentrated under reduced pressure then partitioned between a saturated aqueous solution of NaHCO3 and EtOAc. The organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to afford 2-chloromethyl-benzo[b]thiophene, used as such without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759334B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-3af8ca641c4b4f908efe1476df255b10 |
| 출처 메모 | uspto-grants-2014_06 |