反应详情

温度

80 °C

To a solution of methyl 3-hydroxy-4-ethynylbenzoate (1 eq.) in dry toluene was added PtCl2 (0.1 eq.) under argon. The reaction mixture was stirred at 80° C. for 1.5 h, warmed to 20° C. and the solvents removed under reduced pressure. The crude was purified by chromatography on silica gel (elution with heptane/EtOAc: 9/1) to afford methyl benzofuran-6-carboxylate.

1. temperaturewarmed to 20° C.
2. customthe solvents removed under reduced pressure
3. customThe crude was purified by chromatography on silica gel (elution with heptane/EtOAc: 9/1)