Benzyl Bromide → methyl (2R)-1-benzyl-2-methylazetidine-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-2-methyl-azetidine-2-carboxylic acid methyl ester (1 eq.) in THF were added TEA (2 eq.) and benzyl bromide (1 eq.). The reaction was heated at 50° C. for 15 h. The solvent was concentrated under reduced pressure, the crude was purified by chromatography on silica gel (elution with heptane/EtOAc 1/0 to 1/1) to afford (R)-1-benzyl-2-methyl-azetidine-2-carboxylic acid methyl ester.

Provenance & Evidence