Water → HCID 70559854, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-trifluoromethyl-phenylamine (1 eq.) and ethyl 4-bromobutyrate (2 eq.) in DMF were added K2CO3 (3 eq.) and KI (cat.). The mixture was heated at 100° C. for 16 h, water and EtOAc were added, the organic layer was washed with water, brine, dried over MgSO4, filtered and concentrated under reduced pressure. The crude was purified by chromatography on silica gel (elution with heptane/EtOAc: 90/10 to 70/30) to afford 4-(3-trifluoromethyl-phenylamino)-butyric acid ethyl ester as a yellow oil.

Provenance & Evidence