Tetrahydrofuran → HCID 178457908, compound

Participants

Reaction Steps

To a mixture of 100 mg (0.198 mmol) N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N′-(4-phenethyl-piperidin-4-ylmethyl)-guanidine (example 2) and 29 μl DBU in 5 ml THF 12 μM (0.2 mmol) N-propylisocyanat is dropwise added and stirred at room temperature for 2 h. Then the mixture is concentrated under reduced pressure. The residue is purified via preparative reverse phase HPLC (gradient of acetonitrile and water+0.2% trifluoroacetic acid, 25° C.). Fractions containing the title compound were concentrated under reduced pressure.

Provenance & Evidence