1-(2,3-Dichlorophenyl)piperazine → Aripiprazole

HRID 408646Notes

Reaction equation

HRID 408646 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([CH2:11][CH2:12][C:13](=[O:17])[NH:14]2)=[CH:9][CH:8]=1.[Cl:18][C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH:22]1[CH:21]=[C:20]([N:26]2[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]3[CH:8]=[CH:9][C:10]4[CH2:11][CH2:12][C:13](=[O:17])[NH:14][C:15]=4[CH:16]=3)[CH2:28][CH2:27]2)[C:19]([Cl:18])=[C:24]([Cl:25])[CH:23]=1

Participants

3

Reactant 2

HCID 8518331-(2,3-Dichlorophenyl)piperazineHCID 105420647-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone

Product 1

HCID 60795Aripiprazole

Procedure

7-(4-bromobutoxy)-3,4-dihydrocarbostyril, is reacted with 1-(2,3-dichlorophenyl)piperazine and the thus obtained crude aripiprazole crystals are recrystallized from ethanol.

Sources & evidence

ORD record
ord-c610bcc9ff544455aceb53dd16eabb4d
Source dataset
uspto-grants-2014_06
Patent number
US08759350B2

Reaction notes

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