1,10-Phenanthroline → HCID 68727207, compound

Participants

Reaction Steps

4-Chloro-6-iodo-2-methylquinoline (0.61 g; see Preparation 6(ii) below), 3-pyridyl-carbinol (0.26 g), copper (I) iodide (0.038 g), caesium carbonate (0.78 g), 1,10-phenanthroline (0.072 g) in toluene (3 mL) was heated in a microwave at 160° C. for 40 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate, washed with water, dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica eluting with a mixture of methanol and dichloromethane. Evaporation of the desired fractions gave the title compound as a pale pink solid.

Provenance & Evidence