反应详情

6-Amino-4-chloroquinoline (0.1 g; see step (ii) above), benzaldehyde (0.055 g) and sodium tnacetoxyborohydride (0.22 g) in 1,2-dichloroethane was stirred overnight. The mixture was diluted with dichloromethane and washed with water then dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica eluting with a mixture of ethyl acetate and pentane. The desired fractions were concentrated and the sample evaporated to dryness to give the title compound as an oil.

1. washwashed with water
2. dry with materialthen dried (MgSO4)
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by chromatography on silica eluting with a mixture of ethyl acetate and pentane
6. concentrationThe desired fractions were concentrated
7. customthe sample evaporated to dryness