N,N'-Dimethylethylenediamine → HCID 68725213, compound

Participants

Reaction Steps

4-Chloro-6-iodo-2-methylquinoline (0.61 g; see step (ii) above), 2-pyrrolidinone (0.24 g), copper (I) iodide (0.038 g), potassium phosphate (0.5 g) and N,N′-dimethylethylenediamine (0.035 g) in dimethylformamide (3 mL) were heated in a microwave at 100° C. for 1 hour. The reaction mixture was diluted with 1 N sodium hydroxide and extracted with ethyl acetate, washed with water, dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica eluting with a mixture of dichloromethane, and methanol. The desired fractions were concentrated and the sample evaporated to dryness. Trituration from ether gave the title compound as a white powder (0.2 g).

Provenance & Evidence