Bromobenzene → HCID 25116096, compound

Participants

Reaction Steps

1-(2-Methyl-6-phenoxyquinolin-4-yl)pyrrolidin-3-ylamine (0.107 g; see Example 43 below), bromobenzene (0.058 g), 2-dicyclohexylphosphino-2′-dimethylaminobiphenyl (0.023 g), tris-(dibenzylideneacetone)dipalladium (0.03 g), sodium tert-butoxide (0.044 g) and toluene (3 mL) were heated in a microwave at 150° C. for 20 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate, washed with water, dried (MgSO4), filtered and evaporated to give a brown oil. The residue was purified by chromatography on silica, eluting with a mixture of dichloromethane, and methanol. Evaporation of the desired fractions gave, after trituration with ether, the title compound as a white solid.

Provenance & Evidence