Pyridine → HCID 68776069, compound

Participants

Reaction Steps

2-Methyl-6-amino-4-(3-phenylpyrrolidin-1-yl)quinoline (0.07 g; see Example 45 below), benzenesulfonyl chloride (0.041 g) and pyridine (0.04 g) was stirred in dichloromethane (4 mL). The reaction mixture was diluted with 1 N sodium hydroxide and extracted with ethyl acetate, washed with water, dried (MgSO4), filtered and evaporated to give a brown oil. The residue was purified by chromatography on silica, eluting with a mixture of dichloromethane, and methanol. The desired fractions were concentrated, hydrochloric acid was added, and the sample evaporated to dryness. Trituration from ether gave the title compound as a white solid (0.035 g).

Provenance & Evidence