反应详情

Benzyl-(4-chloro-2-methylquinolin-6-yl)amine (0.041 g; see Preparation 4 above) and 3-phenylpyrrolidine in 2-ethoxyethanol (1 mL) were heated in a microwave to 240° C. for 10 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate, washed with water, dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica, eluting with a mixture of dichloromethane, and methanol. The desired fractions were concentrated and the sample evaporated to dryness. Trituration from ether gave the title compound.

1. extractionextracted with ethyl acetate
2. washwashed with water
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by chromatography on silica
7. washeluting with a mixture of dichloromethane, and methanol
8. concentrationThe desired fractions were concentrated
9. customthe sample evaporated to dryness