3-Benzylpyrrolidine → N-[4-(3-Benzylpyrrolidin-1-yl)-2-methylquinolin-6-yl]benzamide

HRID 408667Notes

Reaction equation

HRID 408667 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:10]=2)[N:5]=[C:4]([CH3:21])[CH:3]=1.[CH2:22]([CH:29]1[CH2:33][CH2:32][NH:31][CH2:30]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([CH:29]1[CH2:33][CH2:32][N:31]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:20])[C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:10]=3)[N:5]=[C:4]([CH3:21])[CH:3]=2)[CH2:30]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 38297913-BenzylpyrrolidineHCID 68726693N-(4-chloro-2-methylquinolin-6-yl)benzamide

Product 1

HCID 25117023N-[4-(3-Benzylpyrrolidin-1-yl)-2-methylquinolin-6-yl]benzamide

Procedure

The title compound was prepared using procedures analogous to those described in Example 1 above, but using N-(4-chloro-2-methylquinolin-6-yl)benzamide (see Preparation 5 above) in place of 4,6-dichloro-2-methylquinoline and 3-benzylpyrrolidine in place of 3-phenylpyrrolidine.

Sources & evidence

ORD record
ord-2f233bc860674f7186a3051f5a5f6ac7
Source dataset
uspto-grants-2014_06
Patent number
US08759348B2

Reaction notes

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