Hydrochloric Acid → HCID 66937236, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1H-pyrazole-4-carboxylic acid ethyl ester (5.00 g, 35.7 mmol), cyanamide (1.50 g, 35.7 mmol), and dioxane (25 mL) was added a solution of 4M HCl in dioxane (9.80 mL, 39.3 mmol). The reaction mixture was heated to 100° C. for 3 h. The reaction was cooled to 23° C. and Et2O (20 mL) was added. The resulting white precipitate was filtered to yield the titled compound (7.26 g, 93%). 1H NMR (400 MHz, DMSO-d6): 9.65 (br m, 4H), 9.29 (s, 1H), 8.43 (s, 1H), 4.31 (q, J=7.1 Hz, 2H), 1.31 (t, J=7.1 Hz, 3H).

Provenance & Evidence