Cesium carbonate → HCID 58379338, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate (0.8 g, 3.6 mmol), cesium carbonate (1.3 g, 3.9 mmol), palladium acetate (64 mg, 0.29 mmol), and triphenylphosphine (0.15 g, 0.57 mmol) in 1,4-dioxane (43 mL) was treated with 1-bromo-3-fluorobenzene (0.54 mL, 4.8 mmol), degassed with nitrogen, and heated in the microwave at 150° C. for 30 min. The reaction mixture was filtered over celite and the filtrate was concentrated to give a crude residue. This material was purified by flash column chromatography to give the desired product (1.2 g, 94%). LCMS for C16H13ClFN2O2 (M+H)+: m/z=319.1.

Provenance & Evidence