Diisopropylethylamine → HCID 178463584, compound

Participants

Reaction Conditions

Reaction Steps

1-[3-(3,5-Difluorophenyl)pyrazolo[1,5-a]pyridin-2-yl]ethanamine trifluoroacetate (16 mg, 0.07 mmol), 6-bromo-9H-purine (13 mg, 0.07 mmol, Aldrich 104981) and N,N-diisopropylethylamine (12 mL, 0.07 mmol) were stirred in ethanol (0.47 mL) and heated to 110° C. for 16 hours. Purification by preparative LCMS (H2O with 0.1% TFA (pH 2), 5% acetonitrile to 24% acetonitrile over 1 minute, 24% to 48% acetonitrile over 12 minutes, Waters Sunfire C18, 5 μM particle size, 30×100 mm, RT=8.75 min.) gave the desired compound (4.0 mg, 12%). LCMS for C20H17F2N7 (M+H)+: m/z=392.0. 1H NMR (300 MHz, DMSO-d6): 8.75 (m, 1H), 8.39 (m, 1H), 8.28 (m, 1H), 7.64 (m, 1H), 7.31 (m, 1H), 7.23 (m, 2H), 7.17 (m, 1H), 6.98 (m, 1H), 5.84 (m, 1H), 1.62 (m, 3H).

Provenance & Evidence