Trifluoroacetic acid → HCID 67434553, compound

Participants

Reaction Steps

Add trifluoroacetic acid (10 mL) to a solution of tert-butyl 4-[8-(2-chlorophenyl)-9-(2-hydroxy-2-methyl-propyl)-2-methyl-purin-6-yl]piperazine-1-carboxylate (1.9 g, 0.0038 mol) in dichloromethane (10 mL) at 0° C. and stir for 2 h at room temperature. Quench the reaction mixture with saturated sodium bicarbonate solution and extract with dichloromethane. Dry the organic layer over anhydrous sodium sulfate, filter, and concentrate to give the title compound (1.5 g). ES/MS m/z 401 (M+1).

Provenance & Evidence