Trifluoroacetic acid → N-tert-Butyl-2-(piperazin-1-ylmethyl)thiazole-4-carboxamide

Participants

Reaction Steps

Tert-butyl 4-((4-(tert-butylcarbamoyl)thiazol-2-yl)methyl)piperazine-1-carboxylate (2.1 g, 5.49 mmol) was dissolved in dichloromethane (20 mL). 2,2,2-Trifluoracetic acid (20 mL) was added and the reaction mixture was stirred for 2 hours. The reaction was concentrated under reduced pressure and purified by SCX column chromatography to give the title compound (1.28 g). MS (ESI) m/z 283.4 [M+H]+

Provenance & Evidence