Trifluoroacetic acid → N-tert-butyl-5-(piperazin-1-ylmethyl)furan-2-carboxamide

Participants

Reaction Steps

Tert-butyl 4-((5-(tert-butylcarbamoyl)furan-2-yl)methyl)piperazine-1-carboxylate (6.57 mmol, 2.4 g) was dissolved in dichloromethane (20 mL). 2,2,2-Trifluoro-acetic acid (20 mL) was added and the reaction mixture was stirred for 2 hours. The reaction was concentrated under reduced pressure and purified by SCX chromatography to give the title compound (1.51 g). MS (ESI) m/z 266.4 [M+H]+

Provenance & Evidence